Evaluation of the <i>TXNIP </i>gene expression in gastric adenocarcinoma and its relationship with overall survival of patients

Background. Gastric Cancer (GC) is a common gastrointestinal tumor, and its incidence increasing. The pathogenesis of GC very complex remains unclear. Recent basic studies have focused on gene expression dysregulation. Accumulating evidence has demonstrated that thioredoxin-interacting protein (TXNIP) abnormally expressed in variety malignant tumors but it obscure GC. This study aimed to compare the TXNIP cancerous adjacent tissue gastric cancer evaluate clinical significance prognosis survival analysis patients. Methods. A total 50 tumor tissues marginal non-tumor control were obtained from Also, levels evaluated by real-time PCR. Meanwhile, bioinformatic approaches used two different cohorts data mining was also performed determine prognostic role overall Furthermore, pan-cancer using TCGA data. Results. down-regulated samples with fold change 0.33, same results repeated bioinformatics analysis. Decreased significantly associated metastasis, poor differentiation, drug abuse. Our provided level positively correlated Pan-cancer revealed tumors. Conclusion. established low as biomarker It decrease likely favors metastatic Practical Implications. Evaluation informative